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Advanced Colorectal Cancer Treatments at Bumrungrad Hospital

22 Jul, 2024

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Colorectal cancer, which affects the colon and rectum, is a significant health concern that can be particularly challenging when diagnosed at an advanced stage. The complexity of treating this type of cancer requires more than just conventional approaches to achieve the best outcomes. For many patients, the array of treatment options can be overwhelming. Traditional methods might not always be enough, and finding the right combination of therapies is crucial for improving survival rates and enhancing quality of life. At Bumrungrad International Hospital in Bangkok, patients facing advanced colorectal cancer have access to some of the most advanced and personalized treatments available. With a focus on cutting-edge therapies and a comprehensive, multidisciplinary approach, Bumrungrad offers hope and effective solutions tailored to each individual’s needs.

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Colorectal cancer

Colorectal cancer, encompassing cancers of the colon and rectum, is a serious health issue with substantial implications for affected individuals. At Bumrungrad International Hospital in Bangkok, the approach to treating colorectal cancer is multifaceted and highly advanced, incorporating the latest technologies and therapies. This blog provides an in-depth look at the sophisticated treatments available at Bumrungrad, highlighting the hospital’s commitment to offering exceptional care for colorectal cancer patients.

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1. Targeted Therapy

Targeted therapy is transforming cancer treatment by focusing on specific molecular targets associated with cancer. Unlike traditional therapies that affect both healthy and cancerous cells, targeted therapies are designed to attack cancer cells with precision, minimizing damage to normal tissues and reducing side effects.

Targeted therapy uses drugs or other substances to precisely identify and attack cancer cells based on their specific characteristics. These therapies work by interfering with particular molecules involved in the growth, progression, and spread of cancer. By targeting these molecular abnormalities, targeted therapy aims to halt cancer's growth and spread more effectively than traditional treatments.


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Types of Targeted Therapy

a. Monoclonal Antibodies: These are lab-made molecules that can bind to specific targets on cancer cells or within the blood. Examples include trastuzumab (Herceptin) for HER2-positive breast cancer and rituximab (Rituxan) for certain lymphomas.
b. Small Molecule Inhibitors: These drugs are designed to penetrate cells and inhibit the action of specific proteins that are involved in cancer cell growth. Examples include imatinib (Gleevec) for chronic myeloid leukaemia and erlotinib (Tarceva) for non-small cell lung cancer.

c. Cancer Vaccines: These vaccines stimulate the immune system to recognize and attack cancer cells. Examples include the HPV vaccine, which helps prevent cervical cancer, and experimental vaccines in clinical trials.


Benefits of Targeted Therapy

1. Precision: Targeted therapy is designed to affect only cancer cells with specific molecular changes, sparing healthy cells and reducing side effects.
2. Efficacy: By focusing on specific cancer-related molecules, targeted therapies can be more effective for certain cancers compared to traditional chemotherapy.
3. Personalization: Treatment can be tailored to the individual's cancer profile, leading to better outcomes and fewer adverse effects.


While targeted therapy offers significant benefits, challenges remain, including the development of resistance by cancer cells and the high cost of treatment. Ongoing research is focused on overcoming these challenges, improving existing therapies, and developing new targeted therapies to treat a broader range of cancers. Targeted therapy represents a major advancement in cancer treatment, offering a more precise and personalized approach to managing cancer. As research progresses, the hope is that targeted therapies will become increasingly effective, helping to improve survival rates and quality of life for cancer patients worldwide.


2. Immunotherapy

Immunotherapy is revolutionizing cancer treatment by leveraging the body's immune system to recognize and destroy cancer cells. At Bumrungrad Hospital, innovative immunotherapy options are being utilized to treat advanced colorectal cancer, offering new hope for patients who may have exhausted other treatment options.


Key Features of Immunotherapy at Bumrungrad Hospital

1. Immune Checkpoint Inhibitors: These drugs target and block proteins like PD-1 or PD-L1, which cancer cells use to evade the immune system. By inhibiting these checkpoints, the immune system's natural ability to detect and kill cancer cells is restored. This approach has shown significant promise in enhancing the immune system's response to cancer cells, leading to more effective treatment outcomes.

2. CAR-T Cell Therapy: CAR-T cell therapy involves modifying a patient's own T cells to recognize and attack cancer cells more effectively. While this therapy is currently more common in treating other cancers, ongoing research at Bumrungrad is exploring its potential for colorectal cancer. The hospital is at the forefront of developing and refining CAR-T cell therapy to offer new treatment avenues for colorectal cancer patients.

3. Cancer Vaccines: Experimental cancer vaccines are designed to stimulate the immune system specifically against colorectal cancer cells. These vaccines aim to train the immune system to target and destroy cancer cells more efficiently. Bumrungrad Hospital is actively investigating these vaccines, with the goal of developing effective immunotherapy options tailored to colorectal cancer.


Benefits of Immunotherapy


1. Enhanced Immune Response: Immunotherapy boosts the body’s natural ability to fight cancer, offering a more targeted approach that can lead to improved efficacy compared to traditional treatments.

2. Long-Term Remission: The potential for prolonged remission is a significant advantage of immunotherapy. By harnessing the immune system’s power, patients may experience extended periods of disease-free survival and improved overall outcomes.


Immunotherapy represents a transformative approach to cancer treatment, and Bumrungrad Hospital is at the cutting edge of this innovation. With advancements in immune checkpoint inhibitors, CAR-T cell therapy, and cancer vaccines, patients with advanced colorectal cancer now have access to promising new treatment options. As research and development continue, the potential for long-term remission and enhanced survival rates offers renewed hope for cancer patients worldwide.


3. Robotic-Assisted Surgery

Robotic-assisted surgery represents a significant advancement in surgical technology, offering unparalleled precision and control. At Bumrungrad Hospital, this state-of-the-art technique is utilized for various colorectal procedures, including resections and tumor removals, enhancing surgical outcomes and patient experiences.


Key Features of Robotic-Assisted Surgery at Bumrungrad Hospital

A. Advanced Robotic Systems: Bumrungrad Hospital employs cutting-edge robotic platforms such as the da Vinci Surgical System. This system provides surgeons with a high-definition 3D view of the surgical site, along with advanced robotic instruments that allow for precise manoeuvring and control. The robotic system’s enhanced visualization and dexterity enable surgeons to perform complex procedures with exceptional accuracy.

B. Minimally Invasive: Robotic-assisted surgery involves making small incisions rather than large open cuts. This minimally invasive approach reduces trauma to the body and lowers the risk of complications. The smaller incisions contribute to reduced postoperative pain, shorter hospital stays, and a quicker return to daily activities compared to traditional open surgery.

C. Enhanced Precision: The robotic system's fine-tuned instruments and 3D visualization enable intricate procedures with greater precision, significantly reducing the likelihood of surgical errors.The improved accuracy of robotic-assisted surgery leads to better overall outcomes, including more successful tumor removals and resections with minimal disruption to surrounding tissues.


Benefits of Robotic-Assisted Surgery


  • Faster Recovery: Patients typically experience shorter hospital stays due to the minimally invasive nature of the procedure.The reduced recovery time allows for a quicker return to normal activities and an overall improvement in quality of life.
  • Reduced Scarring: The small incisions used in robotic-assisted surgery result in less visible scarring, enhancing the cosmetic outcomes of the procedure.


Robotic-assisted surgery at Bumrungrad Hospital exemplifies the forefront of surgical innovation, offering enhanced precision and control through advanced robotic systems. With its minimally invasive approach, this technology not only improves surgical outcomes but also provides patients with faster recovery times and reduced scarring. As robotic-assisted surgery continues to evolve, its role in colorectal procedures and other surgical disciplines is poised to further advance patient care and surgical excellence.


4. Chemotherapy

Chemotherapy remains a cornerstone in the treatment of colorectal cancer, especially in advanced stages where it plays a critical role in managing and potentially overcoming the disease. At Bumrungrad Hospital, cutting-edge chemotherapy regimens are tailored to each patient, ensuring effective treatment while aiming to reduce side effects.


Key Features of Chemotherapy at Bumrungrad Hospital

1. Customized Regimens: Chemotherapy regimens at Bumrungrad are tailored to the unique characteristics of each patient's cancer, including its stage and molecular profile. This personalized approach is designed to maximize the treatment's effectiveness while minimizing adverse effects. By considering the individual patient’s needs, the hospital ensures that the chemotherapy plan is optimized for the best possible outcome.

2. Adjuvant and Neoadjuvant Therapy:

  • Neoadjuvant Therapy: Administered before surgery, this approach aims to shrink tumors and make surgical removal easier. It can also help in reducing the extent of surgery required.
  • Adjuvant Therapy: Given after surgery, this therapy targets any remaining cancer cells to reduce the risk of recurrence and improve long-term outcomes.

3. Supportive Care: The hospital places a strong emphasis on managing side effects such as nausea, fatigue, and immunosuppression. Supportive care is integral to the treatment process, ensuring that patients can maintain their quality of life throughout chemotherapy.


Benefits of Chemotherapy

  • Chemotherapy targets cancer cells throughout the entire body, addressing not just the primary tumor but also potential metastases that may have spread to other areas.

  • Modern chemotherapy protocols have seen significant advancements, enhancing their effectiveness and improving patient survival rates. Continuous research and development contribute to more effective treatments with better outcomes.

  •  Chemotherapy remains a vital and effective component of colorectal cancer treatment at Bumrungrad Hospital. By offering customized regimens, employing both adjuvant and neoadjuvant therapies, and providing comprehensive supportive care, Bumrungrad ensures that patients receive optimal treatment tailored to their specific needs. Advances in chemotherapy protocols continue to improve treatment outcomes and survival rates, making it a crucial option for managing colorectal cancer and enhancing patient care.


    5. Radiation Therapy

    Radiation therapy is a critical tool in the management of colorectal cancer, offering targeted treatment to destroy cancer cells while minimizing damage to surrounding healthy tissues. At Bumrungrad Hospital, advanced radiation therapy techniques are employed to provide effective treatment for localized cancers or as part of palliative care.


    Key Features of Radiation Therapy at Bumrungrad Hospital

    1. Intensity-Modulated Radiation Therapy (IMRT):  IMRT is an advanced form of radiation therapy that modulates the intensity of radiation beams. This allows for precise targeting of high doses directly at the tumor while minimizing exposure to surrounding healthy tissues.  IMRT enhances treatment efficacy by delivering a concentrated dose to the cancer cells, reducing potential side effects and protecting adjacent organs.

    2. Stereotactic Body Radiotherapy (SBRT): SBRT involves delivering high doses of radiation with exceptional precision in a few treatment sessions. It is particularly effective for specific or recurrent tumors. This technique allows for high-dose radiation to be administered with pinpoint accuracy, reducing the number of sessions needed and improving treatment outcomes.

    3. Brachytherapy: Brachytherapy involves placing a radiation source directly inside or very close to the tumor. This method provides targeted treatment for localized cancers, such as those in the rectum. By positioning the radiation source near the tumor, brachytherapy offers a high level of precision and effectiveness for treating cancers that are not suitable for external beam radiation.'


    Benefits of Radiation Therapy

    • Precision Targeting: Advanced radiation techniques like IMRT and SBRT allow for precise targeting of cancer cells, which minimizes damage to adjacent healthy tissues and organs. This precision helps reduce side effects and improve overall treatment tolerance.

  • Effective for Localized Cancers:  Radiation therapy is particularly useful for tumors that cannot be surgically removed or for patients who are not candidates for surgery. It offers a viable alternative to manage and control localized cancers effectively.

  • Radiation therapy at Bumrungrad Hospital represents a sophisticated approach to cancer treatment, combining advanced technologies like IMRT, SBRT, and brachytherapy to provide precise and effective care. These methods enhance the ability to target cancer cells accurately while preserving healthy tissues, offering significant benefits for localized cancers and palliative care. As radiation therapy continues to evolve, its role in comprehensive cancer treatment is crucial in achieving optimal patient outcomes and improving quality of life.


    6. Multidisciplinary Care: Comprehensive and Coordinated Cancer Treatment


    Bumrungrad Hospital's multidisciplinary approach to cancer care ensures that patients benefit from a collaborative team of specialists, each contributing their expertise to create a comprehensive and personalized treatment plan. This integrated approach is designed to enhance patient outcomes and provide holistic management of colorectal cancer.


    Key Features of Multidisciplinary Care at Bumrungrad Hospital

    1. Team Collaboration: The care team includes oncologists, colorectal surgeons, radiologists, pathologists, and supportive care specialists. Each member brings a unique perspective and expertise, working together to develop and implement a tailored treatment plan. This collaborative approach ensures that all aspects of the patient’s condition are considered, from diagnosis to treatment and beyond.

    2. Regular Tumor Board Meetings: Clinical cases are regularly reviewed in tumor board meetings where specialists discuss and evaluate treatment strategies based on the latest patient data. These meetings allow for real-time adjustments to treatment plans, ensuring that the approach remains effective and responsive to changes in the patient’s condition.

    3. Integrated Care Plans: Integrated care plans address all facets of the patient’s health, including psychological, nutritional, and supportive needs. This comprehensive management ensures that no aspect of the patient’s well-being is overlooked.


    Benefits of Multidisciplinary Care

    • By involving various specialists, the multidisciplinary approach ensures that all aspects of the patient’s condition are managed effectively, leading to better overall care and outcomes.
    • The coordinated efforts of the care team streamline the treatment process, reduce duplication of efforts, and enhance the efficiency and effectiveness of ca

    7. Supportive and Palliative Care: Enhancing Quality of Life


    Supportive and palliative care at Bumrungrad Hospital focuses on improving the quality of life for patients with colorectal cancer by addressing symptoms and providing comprehensive emotional and psychological support. This care is crucial for managing the challenges of cancer and its treatment, ensuring patients can maintain comfort and dignity.


    Key Features of Supportive and Palliative Care at Bumrungrad Hospital

    1. Pain Management: Pain management includes both pharmacological options and non-pharmacological methods to alleviate discomfort and improve overall comfort. Techniques may involve medications, physical therapy, and alternative therapies. The goal is to ensure patients experience the least amount of pain possible, enhancing their quality of life during treatment.

    2. Nutritional Support: Patients receive individualized dietary plans to ensure they get adequate nutrition, manage side effects, and support their overall health. This can include special diets tailored to their treatment and nutritional needs. Nutritional support helps in maintaining strength and energy, which is vital for coping with treatment and improving recovery.

    3. Psychological Counseling: Psychological counselling provides emotional and mental health support to patients and their families. It helps in coping with the stresses and emotional challenges associated with a cancer diagnosis and treatment. Support includes one-on-one counselling, group therapy, and family support to address the emotional aspects of dealing with cancer.


    Benefits of Supportive and Palliative Care

    • The focus on symptom management and comfort helps improve overall well-being, allowing patients to live more comfortably during their treatment.
    • Addressing both physical and emotional needs ensures that patients receive well-rounded care, improving their overall experience and providing necessary support throughout their cancer journey.

     Bumrungrad Hospital’s multidisciplinary approach and supportive and palliative care services exemplify a commitment to comprehensive, patient-centred care. The integration of specialist expertise and holistic support ensures that patients with colorectal cancer receive optimal treatment and enhanced quality of life. This thorough approach to cancer care reflects a dedication to addressing every aspect of patient well-being, leading to better outcomes and improved overall experiences for those undergoing treatment.


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    Advanced treatments for colorectal cancer at Bumrungrad International Hospital reflect the institution's commitment to providing cutting-edge, personalized care. From targeted and immunotherapy to robotic-assisted surgery and comprehensive supportive care, Bumrungrad offers a holistic approach to managing colorectal cancer. The integration of these advanced therapies, supported by a multidisciplinary team, ensures that patients receive the most effective and compassionate care available.

    For patients seeking advanced colorectal cancer treatment, Bumrungrad International Hospital stands out as a beacon of innovation and excellence, dedicated to improving outcomes and enhancing the quality of life through every stage of treatment.

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    Supportive and palliative care includes pain management, nutritional support, and psychological counseling to improve the quality of life for patients.